Siramesine fumarate

Overview

Siramesine (Lu 28-179) fumarate is a potent sigma-2 receptor agonist. Siramesine fumarate has a subnanomolar affinity for sigma-2 receptors ( IC 50 =0.12?nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors ( IC 50 =17?nM). Siramesine fumarate triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Sigma Receptor

Product Information

• Catalog No.: HY-14221B
• CAS No.: 163630-79-3
• Molecular Formula: C34H35FN2O5
• Molecular Weight: 570.65
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source