HDAC-IN-27

Overview

HDAC-IN-27 (Compound 11h) is a potent, orally active class I HDAC -selective inhibitor with IC 50 values ranging from 0.43 to 3.01 nM against HDAC1-3 . HDAC-IN-27 exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation ( AcHH3 and AcHH4 ). HDAC-IN-27 can be used for research in acute myeloid leukemia (AML).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-142690
• CAS No.: 2763368-89-2
• Molecular Formula: C20H22N4O2
• Molecular Weight: 350.41
• Purity: 98.12%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source