HDAC-IN-27 dihydrochloride

Overview

HDAC-IN-27 dihydrochloride (Compound 11h) is a potent, orally active class I HDAC -selective inhibitor with IC 50 values ranging from 0.43 to 3.01 nM against HDAC1-3 . HDAC-IN-27 dihydrochloride exhibits both in vivo and in vitro antitumor activity. HDAC-IN-27 dihydrochloride demonstrates significant anti-proliferative activity against acute myeloid leukemia (AML) cell lines by inducing apoptosis and histone acetylation ( AcHH3 and AcHH4 ). HDAC-IN-27 dihydrochloride can be used for research in acute myeloid leukemia (AML).

Application

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Product Information

• Catalog No.: HY-142690A
• CAS No.: 3069831-25-7
• Molecular Formula: C20H24Cl2N4O2
• Molecular Weight: 423.34
• Purity: 99.08%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 1.25 mg/mL (2.95 mM); Clear solution
• Availability: In-stock

Source

Original product source