CDK6/PIM1-IN-1

Overview

CDK6/PIM1-IN-1 is a potent and balanced dual CDK6/PIM1 inhibitor with IC 50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 inhibits CDK4 (IC 50 =3.6 nM). CDK6/PIM1-IN-1 significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis . CDK6/PIM1-IN-1 exhibits potent anti-AML activity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > CDK | Products > Signaling Pathways > Pim | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-142696
• CAS No.: 2677026-14-9
• Molecular Formula: C25H28FN9
• Molecular Weight: 473.55
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source