BRD4 D1-IN-2 (compound 26) is a potent and selective BRD4 D1 inhibitor ( IC 50 <0.092 µM). BRD4 D1-IN-2 has 15 nM affinity against BRD4 D1 and over 500-fold selectivity against BRD2 D1 and BRD4 D2 via ITC.
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