Entacapone sodium salt

Overview

Entacapone sodium salt is a potent, reversible, peripherally acting and orally active catechol-O-methyltransferase ( COMT ) inhibitor. Entacapone sodium salt inhibits COMT from rat brain, erythrocytes and liver with IC 50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone sodium salt is selective for COMT over other catecholamine metabolizing enzymes , including MAO-A , MAO-B , phenolsulphotransferase M (PST-M) and PST-P (IC 50 s>50 µM). Entacapone sodium salt can be used for the research of Parkinson's disease. Entacapone sodium salt serves as as a inhibit of FTO demethylation with an IC 50 of 3.5 μM, can be used for the research of metabolic disorders.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Neurological Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > COMT

Product Information

• Catalog No.: HY-14280A
• CAS No.: 1047659-02-8
• Molecular Formula: C14H14N3NaO5
• Molecular Weight: 327.27
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source