GEM144

Overview

GEM144 is a potent and orally active DNA polymerase α ( POLA1 ) and HDAC 11 dual inhibitor. GEM144 induces acetylation of p53 , activation of p21 , G1/S cell cycle arrest, and apoptosis . GEM144 has significant antitumor activity in human orthotopic malignant pleural mesothelioma xenografts.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Pancreatic Cancer | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-143411
• CAS No.: 2487526-28-1
• Molecular Formula: C28H31NO5
• Molecular Weight: 461.55
• Purity: 99.98%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.83 mM); Clear solution
• Availability: In-stock

Source

Original product source