Pan-Trk-IN-3

Overview

Pan-Trk-IN-3 (Compound 11g) is a potent inhibitor of pan- Trk and their drug-resistant mutants with IC 50 values of 2, 3, 2, 21, 26, 5, 7 and 6 nM against TrkA , TrkB , TrkC , TrkA G595R , TrkA G667C , TrkA G667S , TrkA F589L and TrkC G623R , respectively. Pan-Trk-IN-3 displays excellent antitumor activity and induces apoptosis .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Trk Receptor | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-144069
• CAS No.: 2763637-66-5
• Molecular Formula: C29H31ClN8O3
• Molecular Weight: 575.06
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source