PPARα/δ agonist 1 is a potent PPARα/PPARδ dual agonist ( PPARα EC 50 =7.0 nM; PPARδ EC 50 =8.4 nM). PPARα/δ agonist 1 is a high selectivity over PPARγ ( PPARγ EC 50 =1316.1 nM). PPARα/δ agonist 1 has the potential for the research of nonalcoholic steatohepatitis.
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