PARP1/BRD4-IN-1 is a potent and high selective PARP1 / BRD4 inhibitor ( IC 50 s of 49 and 202 nM in PARP1 and BRD4, respectively). PARP1/BRD4-IN-1 represses the expression and activity of PARP1 and BRD4 to synergistically inhibit the malignant growth of pancreatic cancer cells.
Products | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > DNA/RNA Synthesis
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