Pyridone 6

Overview

Pyridone 6 is a pan-JAK inhibitor, which potently inhibits the JAK kinase family, with IC 50 s of 1 nM for JAK2 and TYK2 , 5 nM for JAK3 , and 15 nM for JAK1 , while displaying significantly weaker affinities (130 nM to >10 mM) for other protein tyrosine kinases.

Application

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Product Information

• Catalog No.: HY-14435
• CAS No.: 457081-03-7
• Molecular Formula: C18H16FN3O
• Molecular Weight: 309.34
• Purity: 98.20%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (8.08 mM); Clear solution
• Availability: In-stock

Source

Original product source