Trk-IN-10

Overview

Trk-IN-10 (Compound 14j) is a potent inhibitor of TRK ( IC 50 = 0.86, 6.92 nM, against TrkA , TrkA G595R , respectively). As a receptor tyrosine kinase (RTK), tropomyosin receptor kinase ( Trk ) is a key agent target in solid tumors. Trk-IN-10 ( IC 50 = 350 nM against ALK) has a higher selectivity of Trk inhibition, which may be of great significance for reducing toxicity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-144423
• CAS No.: 2700265-61-6
• Molecular Formula: C20H20FN5O3
• Molecular Weight: 397.40
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source