TRK-IN-12

Overview

TRK-IN-12 (Compound 9e) is a potent inhibitor of TRK ( TRK G595R IC 50 = 13.1 nM). TRK-IN-12 is a macrocyclic derivative compound. TRK-IN-12 shows significant antiproliferative activity in the Ba/F3-LMNA-NTRK1 cell line ( IC 50 = 0.080 μM). TRK-IN-12 has shown a better inhibitory effect ( IC 50 = 0.646 μM) than control agent LOXO-101 in Ba/F3-LMNA-NTRK1-G595R cell line.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Trk Receptor

Product Information

• Catalog No.: HY-144451
• CAS No.: 2823342-34-1
• Molecular Formula: C18H19ClFN5O3S
• Molecular Weight: 439.89
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source