D18

Overview

D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC 50 = 24 nM for hTLR7 and 10 nM for hTLR8, respectively). D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2 ( HY-144497 ). D18 has strong immune activation and anti-tumor activity. D18 commonly used in cancer research, such as colon cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > PD-1/PD-L1

Product Information

• Catalog No.: HY-144501
• CAS No.: 2230218-36-5
• Molecular Formula: C21H28N6
• Molecular Weight: 364.49
• Purity: 98.14%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (6.86 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source