LSD1-IN-13 (compound 7e) is an orally active and potent LSD1 inhibitor, with an IC 50 of 24.43 nM. LSD1-IN-13 can activate CD86 expression, with an EC 50 of 470 nM. LSD1-IN-13 induces differentiation of AML (acute myeloid leukemia) cell lines.
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