UNC6934

Overview

UNC6934 is a selective NSD2-PWWP1 antagonist with a K d of 91 nM against human targets. UNC6934 binds to the canonical methyl-lysine binding pocket of NSD2-PWWP1 and directly competes with H3K36me2 for binding. UNC6934 induces the aggregation of NSD2 within the nucleolus, without altering ribosomal RNA transcription, global H3K36me2 levels or the proliferation of KMS-11 cells. UNC6934 can be used in studies related to multiple myeloma and diffuse intrinsic pontine glioma.

Application

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Product Information

• Catalog No.: HY-145103
• CAS No.: 2561494-77-5
• Molecular Formula: C24H21N5O4
• Molecular Weight: 443.45
• Purity: 98.24%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution
• Availability: In-stock

Source

Original product source