OM-153

Overview

OM-153 is a potent and orally active tankyrase inhibitor with IC 50 s of 13 nM and 2 nM for tankyrase 1 and tankyrase 2 ( TNKS1/2 ), respectively. OM-153 inhibits luciferase-based Wnt/β-catenin signaling reporter activity with an IC 50 value of 0.63 nM. OM-153 shows inhibition of Wnt/β-catenin signaling and proliferation in COLO 320DM.

Application

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Product Information

• Catalog No.: HY-145267
• CAS No.: 2406278-81-5
• Molecular Formula: C28H24FN7O2
• Molecular Weight: 509.53
• Purity: 99.30%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (4.91 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source