GSK3179106

Overview

GSK3179106 is an orally active and selective RET kinase inhibitor with IC 50 s of 0.4 nM, 0.2 nM for human RET and rat RET , respectively. GSK3179106 has the potential for irritable bowel syndrome (IBS) through the attenuation of post-inflammatory and stress-induced visceral hypersensitivity.

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Liver Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RET

Product Information

• Catalog No.: HY-100459
• CAS No.: 1627856-64-7
• Molecular Formula: C22H21F4N3O4
• Molecular Weight: 467.41
• Purity: 99.81%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.5 mg/mL (5.35 mM); Clear solution
• Availability: In-stock

Source

Original product source