AGI-41998

Overview

AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A ( MAT2A ) that effectively penetrates the blood-brain barrier. AGI-41998 exhibits inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC 50 s of 22 nM and 34 nM. AGI-41998 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-41998 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer .

Application

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Product Information

• Catalog No.: HY-145778
• CAS No.: 2377492-26-5
• Molecular Formula: C22H16BrF3N4O2
• Molecular Weight: 505.29
• Purity: 98.72%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution
• Availability: In-stock

Source

Original product source