MRTX-EX185

Overview

MRTX-EX185 is a potent KRAS (G12D) inhibitor with an IC 50 of 90 nM. MRTX-EX185 can binds both GDP-loaded and active GNP states of KRAS and KRAS (G12D) . MRTX-EX185 exhibits broad-spectrum binding properties with IC 50 s of 110, 290, 130 and 240 nM for KRAS WT , KRAS (G12C) , KRAS (Q61H) , KRAS (G13D) . MRTX-EX185 also binds GDP-loaded HRAS . MRTX-EX185 can be used to study various RAS-driven tumors (such as pancreatic cancer ) .

Application

Products | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-145962
• CAS No.: 2621927-57-7
• Molecular Formula: C33H33FN6O2
• Molecular Weight: 564.65
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source