MRTX-EX185 formic

Overview

MRTX-EX185 formic is a potent KRAS (G12D) inhibitor with an IC 50 of 90 nM. MRTX-EX185 formic can binds both GDP-loaded and active GNP states of KRAS and KRAS (G12D) . MRTX-EX185 formic exhibits broad-spectrum binding properties with IC 50 s of 110, 290, 130 and 240 nM for KRAS WT , KRAS (G12C) , KRAS (Q61H) , KRAS (G13D) . MRTX-EX185 formic also binds GDP-loaded HRAS . MRTX-EX185 formic can be used to study various RAS-driven tumors (such as pancreatic cancer ) .

Application

Products | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-145962A
• CAS No.: 2988148-70-3
• Molecular Formula: C34H35FN6O4
• Molecular Weight: 610.68
• Purity: 97.15%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.08 mg/mL (3.41 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source