EGFR-IN-57

Overview

EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC 50 of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2 , CK2α , topoisomerase IIβ and tubulin polymerization with IC 50 values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis .

Application

Products | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Casein Kinase | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > Microtubule/Tubulin | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > VEGFR

Product Information

• Catalog No.: HY-146138
• CAS No.: 2492382-37-1
• Molecular Formula: C22H15N3O2S
• Molecular Weight: 385.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source