(3R,10R,14aS)-AZD4625

Overview

(3R,10R,14aS)-AZD4625 is the isomer of AZD4625 ( HY-146223 ), and can be used as an experimental control. AZD4625 is an orally active, selective irreversible, covalent allosteric GTPase KRAS G12C inhibitor with an IC 50 of 3 nM. AZD4625 can inhibit the MAPK pathway (with decreased pCRAF, pMEK, and pERK ) and the PI3K pathway (with decreased pAKT and pS6), and induce cell apoptosis . AZD4625 has no binding and inhibition of wild-type RAS or isoforms carrying non-KRAS G12C mutations. AZD4625 can be used for the study of KRAS G12C mutant non-small cell lung cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ras | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-146223A
• CAS No.: 2387927-95-7
• Molecular Formula: C24H21ClF2N4O3
• Molecular Weight: 486.90
• Purity: 98.00%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.27 mM); Clear solution
• Availability: In-stock

Source

Original product source