ALK-IN-21

Overview

ALK-IN-21 (Compound B10), a potent ALK inhibitor for ALKG1202R mutation, exhibits remarkable enzymatic inhibitory potency with IC 50 values of 4.59 nM, 2.07 nM and 5.95 nM toward ALK WT , ALK L1196M and ALK G1202R , respectively. ALK-IN-21 efficiently inhibits the proliferation of ALK-positive Karpas299 and H2228 cells both with IC 50 values of 0.07 μM. ALK-IN-21 can be used for the research of anaplastic large cell lymphoma.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK)

Product Information

• Catalog No.: HY-146408
• CAS No.: 2901889-01-6
• Molecular Formula: C35H45ClN6O6S4
• Molecular Weight: 809.48
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source