GEM-5

Overview

GEM-5 is a gemcitabine-based conjugate containing a HIF-1α inhibitor (YC-1) ( IC 50 =30 nM). GEM-5 can significantly down-regulate the expression of HIF-1α and up-regulate the expression of tumor suppressor p53 . GEM-5 induces the apoptosis of A2780 cells and inhibits tumor growth.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > HIF/HIF Prolyl-Hydroxylase | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MDM-2/p53

Product Information

• Catalog No.: HY-146540
• CAS No.: 2233543-49-0
• Molecular Formula: C32H29F2N5O8
• Molecular Weight: 649.60
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source