PD-1/PD-L1-IN-27 is a potent PD-1/PD-L1 inhibitor with an IC 50 value of 134 nM. PD-1/PD-L1-IN-27 shows antitumor effects with low T cell cytotoxicity. PD-1/PD-L1-IN-27 has the ability to activate CD8 + T cells and reduces T cell exhaustion.
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