GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC 50 s of 11.4 µM and 6.8 µM for GLUT1 and GLUT4 , respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity.
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