Selvigaltin

Overview

Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC 50 value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen ). Selvigaltin restores T-cell activity and induces less tumors and metastasis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > Galectin

Product Information

• Catalog No.: HY-147041
• CAS No.: 1978336-95-6
• Molecular Formula: C19H16BrF3N4O4S
• Molecular Weight: 533.32
• Purity: 99.89%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (4.69 mM); Clear solution
• Availability: In-stock

Source

Original product source