CAY10789

Overview

CAY10789 is a potent CysLT1R (cysteinyl leukotriene receptor 1) antagonist ( IC 50 =2.80 μM) and GPBAR1 (G-protein-coupled bile acid receptor 1) agonist ( EC 50 =3 μM). CAY10789 significantly reduces the adhesion of U937 cells to HAEC, reduces the expression of TNF-α. CAY10789 shows very promising metabolic stability and excellent pharmacokinetics. CAY10789 can be used for the research of colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases.

Application

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Product Information

• Catalog No.: HY-147086
• CAS No.: 123226-28-8
• Molecular Formula: C17H15NO2
• Molecular Weight: 265.31
• Purity: 99.84%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (9.42 mM); Clear solution
• Availability: In-stock

Source

Original product source