MYF-03-69

Overview

MYF-03-69 (TEAD-IN-3) is a covalent and irreversible TEAD inhibitor with IC 50 s of 385, 143, 558 and 173 nM for TEAD1 , TEAD2 , TEAD3 and TEAD4 . MYF-03-69 disrupts YAP-TEAD association, suppresses TEAD transcriptional activity ( IC 50 = 56 nM) and up-regulates apoptosis gene BMF . MYF-03-69 selectively inhibits mesothelioma cancer cells with defective Hippo signaling. MYF-03-69 can be used for the study of malignant pleural mesothelioma (MPM).

Application

Products | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Lung Fibrosis | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > YAP | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-147135
• CAS No.: 2416418-11-4
• Molecular Formula: C22H20F3N5O2
• Molecular Weight: 443.42
• Purity: 98.11%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (5.64 mM); Clear solution
• Availability: In-stock

Source

Original product source