MYF-03-176

Overview

MYF-03-176 is an orally active inhibitor of TEAD , and suppresses TEAD transcriptional activity with an IC 50 of 11 nM. The IC 50 values of MYF-03-176 for TEAD1, TEAD3, and TEAD4 are 47, 32, and 71 nM, respectively. MYF-03-176 inhibits hippo signaling defective malignant pleural mesothelioma (MPM) cells. MYF-03-176 shows strong antitumor efficacy in MPM mouse xenograft model.

Application

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Product Information

• Catalog No.: HY-147136
• CAS No.: 2857937-59-6
• Molecular Formula: C19H18F4N4O2
• Molecular Weight: 410.37
• Purity: 99.72%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution
• Availability: In-stock

Source

Original product source