GNE-7883

Overview

GNE-7883 is a pan- TEAD inhibitor that blocks the association of YAP/TAZ with TEAD . GNE-7883 effectively reduces chromatin accessibility at TEAD motifs, inhibits cell proliferation in multiple cell line models, and achieves strong anti-tumor efficacy in vivo. In addition, GNE-7883 effectively overcomes intrinsic and acquired resistance to KRAS (Kirsten rat sarcoma viral oncogene homolog) G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation.

Application

Products | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Signaling Pathways > YAP

Product Information

• Catalog No.: HY-147214
• CAS No.: 2648450-42-2
• Molecular Formula: C28H29FN6O2
• Molecular Weight: 500.57
• Purity: 99.54%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (4.99 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source