Tinlorafenib

Overview

Tinlorafenib (PF-07284890) is the orally active inhibitor for BRAF and CRAF with IC 50 s of 5.8 nM and 4.1 nM. Tinlorafenib (Compound 10) inhibits V600E mutated BRAF and V600K mutanted BRAF with IC 50 s of 4.25 nM and 2.7 nM. Tinlorafenib can cross the blood brain barrier. Tinlorafenib demonstrates CNS penetration and can be used in the research of BRAF -associated malignant and benign tumors of the CNS as well as extracranial malignancies.

Application

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Product Information

• Catalog No.: HY-147405
• CAS No.: 2573781-75-4
• Molecular Formula: C19H19ClF2N4O3S
• Molecular Weight: 456.89
• Purity: 98.21%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (4.55 mM); Clear solution
• Availability: In-stock

Source

Original product source