TPB15

Overview

TPB15 is an orally active and potent Hh ( Hedgehog ) signaling inhibitor. TPB15 markedly induces cell cycle arrest and apoptosis in MDA-MB-468 cells. TPB15 blocks Smo (Smoothened) translocation into the cilia and reduced Smo protein and mRNA expression. TPB15 inhibits the expression of the downstream regulatory factor glioma-associated oncogene 1 ( Gli1 ). TPB15 shows good anti-tumor activity with low toxicity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Hedgehog | Products > Signaling Pathways > Smo | Products > Signaling Pathways > Gli | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-147670
• CAS No.: 2170347-69-8
• Molecular Formula: C18H9Cl4N5O
• Molecular Weight: 453.11
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source