MDH1-IN-2

Overview

MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC 50 values of 2.27 and 27.47 μM for MDH1 and MDH2 , respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid ( HY-W013636 ) to α-Hydroxyglutaric acid ( HY-113038B ) mediated by MDH1 , thereby suppressing 2-Ketoglutaric acid ( HY-W013636 )-induced ferroptosis .

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Malate Dehydrogenase (MDH)

Product Information

• Catalog No.: HY-147791
• CAS No.: 2143463-35-6
• Molecular Formula: C25H33NO5
• Molecular Weight: 427.53
• Purity: 98.70%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 1 mg/mL (2.34 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source