B-Raf IN 8 (compound 7g) is a potent B-Raf inhibitor, with an IC 50 of 70.65 nM. B-Raf IN 8 exhibits antitumor activity against hepatocellular carcinoma (HEPG-2), colon carcinoma (HCT-116), mammary gland (MCF-7) and human prostate cancer (PC-3) cells, with IC 50 values of 9.78, 13.78, 18.52 and 29.85 µM.
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