B-Raf IN 9 (compound 8b) is a potent B-Raf inhibitor, with an IC 50 of 24.79 nM. B-Raf IN 9 induces apoptosis and shows cell cycle arrest at G2/M phase. B-Raf IN 9 exhibits potent antitumor activity against human prostate cancer PC-3 cell line, with an IC 50 of 7.83 µM.
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