Landiolol hydrochloride

Overview

Landiolol (ONO1101) hydrochloride is a highly selective, ultra-short-acting competitive inhibitor of β 1 adrenergic receptors . Landiolol hydrochloride specifically blocks cardiac β 1 receptors, reducing heart rate and myocardial oxygen consumption. Landiolol hydrochloride inhibits TNF-α -induced excessive mitochondrial oxygen consumption and reactive oxygen species production in a sepsis model, alleviating renal injury. Landiolol hydrochloride has little effect on cardiac ion channels (such as L-type calcium current and inward rectifier potassium current ) and has a weak negative inotropic effect. Landiolol hydrochloride can be used for perioperative tachycardia control and protection studies of sepsis-related acute kidney injury.

Application

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Product Information

• Catalog No.: HY-100607A
• CAS No.: 144481-98-1
• Molecular Formula: C25H40ClN3O8
• Molecular Weight: 546.05
• Purity: 99.82%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.08 mg/mL (3.81 mM); Clear solution
• Availability: In-stock

Source

Original product source