M4K2234

Overview

M4K2234, a chemical probe, is an orally active, highly selective inhibitor of ALK1 and ALK2 with IC 50 values of 7 nM and 14 nM, respectively. M4K2234 specifically blocks BMP signaling by inhibiting the phosphorylation of SMAD1/5/8 . M4K2234 inhibits BMP7-stimulated reporter gene activity ( IC 50 = 16 nM). M4K2234 can be used for the investigation of ALK1/2-mediated biological processes and related diseases such as diffuse midline glioma (DMG) and fibrodysplasia ossificans progressiva (FOP).

Application

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Product Information

• Catalog No.: HY-148234
• CAS No.: 2421141-51-5
• Molecular Formula: C27H31FN4O2
• Molecular Weight: 462.56
• Purity: 98.31%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source