LT-626

Overview

LT-626 is a potent PARP inhibitor with an IC 50 of 1.60 nM. LT-626 inhibits cellular PAR synthesis with an EC 50 of 17.9 nM and shows enhanced cytotoxicity in colorectal cancer cells harboring MRE11 mutations. LT-626 exhibits synergistic effects with Cisplatin ( HY-17394 ), Oxaliplatin ( HY-17371 ), and SN-38 ( HY-13704 ) in colorectal cancer cells. LT-626 can be used for colorectal research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PARP

Product Information

• Catalog No.: HY-148302
• CAS No.: 1207456-03-8
• Molecular Formula: C20H15F2N5O
• Molecular Weight: 379.37
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source