NAMPT/IDO1-IN-1

Overview

NAMPT/IDO1-IN-1 is an orally active dual inhibitor of NAMPT and IDO1 with IC 50 s of 57.7 nM and 233 nM, respectively. NAMPT/IDO1-IN-1 blocks NAD+ biosynthesis, inhibits proliferation and migration of Paclitaxel ( HY-B0015 )- and FK866 ( HY-50876 )-resistant NSCLC cell lines (A549/R cells). NAMPT/IDO1-IN-1 has shown antitumor effects in mice and enhanced A549/R cell sensitivity to paclitaxel.

Application

Products | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Indoleamine 2,3-Dioxygenase (IDO) | Products > Signaling Pathways > NAMPT

Product Information

• Catalog No.: HY-148572
• CAS No.: 2247884-06-4
• Molecular Formula: C23H24BrFN8O3
• Molecular Weight: 559.39
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source