ZJH-16 (Compound 11e) is an orally active EED inhibitor ( IC 50 = 2.72 nM, K d = 4.4 nM). ZJH-16 inhibits the growth of lymphoma cells and reduces H3K27 trimethylation levels. ZJH-16 inhibits tumor growth in lymphoma animal models. ZJH-16 can be used for research on lymphoma and other cancers.
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