Zavondemstat

Overview

Zavondemstat (QC8222 free base; TACH 101 free base) is an orally active pan- KDM4 inhibitor, with a IC 50 ≤ 0.08 μM against human KDM4A-D and a Kᵢ of 0.52 μM against human KDM4C. Zavondemstat induces cell apoptosis , causes S-phase cell cycle arrest, reduces the population of tumor-initiating cells and inhibits cancer cell proliferation. Zavondemstat suppresses tumor growth and induces tumor regression in mouse xenograft models. Zavondemstat can be used for the research of various cancers including colorectal cancer , esophageal squamous cell carcinoma and triple-negative breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Demethylase | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-148807
• CAS No.: 1851412-93-5
• Molecular Formula: C26H29N3O3
• Molecular Weight: 431.53
• Purity: 99.29%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 1 mg/mL (2.32 mM); Clear solution
• Availability: In-stock

Source

Original product source