NP10679

Overview

NP10679 is a selective, pH dependent GluN2B subunit -specific N-methyl-D-aspartate ( NMDA ) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC 50 s of 23 and 142 nM at pH 6.9 and 7.6, respectively. NP10679 is a histamine H1 antagonist and a hERG channel inhibitor with IC 50 s of 73 and 620 nM, respectively. NP10679 is a reversible inhibitor of human liver CYP enzymes .

Application

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Product Information

• Catalog No.: HY-148825
• CAS No.: 2914889-88-4
• Molecular Formula: C23H26F3N3O3
• Molecular Weight: 449.47
• Purity: 98.40%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (5.56 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source