GSK-3β inhibitor 13

Overview

GSK-3β inhibitor 13 (compound 47) is an orally active and potent GSK-3β inhibitor with blood-brain permeability. GSK-3β inhibitor 13 inhibits GSK-3β and GSK-3α with IC 50 s of 0.73 nM and 0.35 nM, respectively. GSK-3β inhibitor 13 significantly decreases the phosphorylation of tau ( IC 50 =58 nM), which leads the formation of the neurofibrillary tangles associated with Alzheimer's disease.

Application

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Product Information

• Catalog No.: HY-149054
• CAS No.: 2227316-74-5
• Molecular Formula: C23H22N6O2
• Molecular Weight: 414.46
• Purity: 99.74%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source