USP28-IN-3

Overview

USP28-IN-3 is a USP28 inhibitor ( IC 50 =0.1 μM) with high selectivity over USP2 , USP7 , USP8 , USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro . USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib ( HY-10331 ).

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Deubiquitinase

Product Information

• Catalog No.: HY-149229
• CAS No.: 2931509-14-5
• Molecular Formula: C23H20Cl2N2O3S
• Molecular Weight: 475.39
• Purity: 98.26%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.26 mM); Clear solution
• Availability: In-stock

Source

Original product source