USP28-IN-4

Overview

USP28-IN-4 is a USP28 inhibitor ( IC 50 =0.04 μM) with high selectivity over USP2 , USP7 , USP8 , USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro . USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib ( HY-10331 ).

Application

Products | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Deubiquitinase

Product Information

• Catalog No.: HY-149230
• CAS No.: 2931509-15-6
• Molecular Formula: C22H18Cl2N2O3S
• Molecular Weight: 461.36
• Purity: 98.86%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Availability: In-stock

Source

Original product source