TrxR1-IN-1 (Compound 5j) is a TrxR1 inhibitor ( IC 50 : 8.8 μM). TrxR1-IN-1 has anticancer activity, with IC 50 s of MCF-7 (1.5 μM), HeLa (1.7 μM), BGC-823 (2.4 μM), SW-480 (2.8 μM), A549 (2.1 μM). TrxR1-IN-1 has antioxidant activity, and scavenges DPPH radical.
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