MET/PDGFRA-IN-1

Overview

MET/PDGFRA-IN-1 (compound 8c) is a MET and PDGFRA protein inhibitor ( IC 50 : 36 μM for MET). MET/PDGFRA-IN-1 inhibits MET phosphorylation and induces cell apoptosis . MET/PDGFRA-IN-1 inhibits proliferation of MET-positive cells (IC 50 s: 15.3, 19.0, 22.0, 25.6, 21.0, 31.5 μM for AsPc-1, EBC-1, MKN-45, Mia-Paca-2, HT-29, K562 cells respectively).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > c-Met/HGFR | Products > Signaling Pathways > PDGFR | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-149510
• CAS No.: 3125694-48-3
• Molecular Formula: C26H23N7O
• Molecular Weight: 449.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source