ICMT-IN-53 (compound 12) is an ICMT inhibitor ( IC 50 =0.96 μM) with PAMPA permeability and antiproliferative activity. ICMT-IN-53 inhibits the proliferation of MDA-MB-231 and PC3 with IC 50 s of 5.14 μM and 5.88 μM, respectively.
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